South Andaman district, which is one of the 3 districts of the Indian Union Territory of Andaman and Nicobar Islands, is located in the Bay of Bengal. Port Blair town, which is the capital of the Union Territory is the district headquarters. South Andaman Island is the southernmost island of the Great Andaman and majority of the population of the Andaman Islands lives here. Port Blair, which is the capital of the islands, is located on the southern part of this island. Some areas of the island are restricted for non-Indians. However, transit permits can be obtained from the Home Ministry to visit these areas. Like the rest of the archipelago, it was devastated by the 2004 Indian Ocean earthquake, leading to many deaths on the island.

It is the third largest island in the island group. It is located immediately south of Middle Andaman Island, from which it is segregated only by a narrow channel, a few hundred meters wide. South Andaman is less mountainous compared to the more northerly of the Andaman Islands. Koiob has an altitude of 456.6 meters. This district was formed on August 18, 2006 by bifurcating the former Andaman district.